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Reduction in Left Frontal Alpha Oscillations by Transcranial Alternating Current Stimulation in Major Depressive Disorder Is Context Dependent in a Randomized Clinical Trial

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249,250 While the methylation rate of CpG islands is elevated during mouse brain development, SHANK3 is upregulated two weeks postnatal, suggesting that methylation of CpG islands is a strong regulator of SHANK3 expression