During IS, tau protein decreases, generous free iron deposits, and then Fe 2+ releases electrons, producing excessive ROS
Excessive intracellular levels of iron ions generate hydroxyl radicals through the Fenton reaction interacting with hydrogen peroxide, thus promoting the production of reactive oxygen species (ROS), which cause lipid peroxidation and are believed to be the primary driver of ferroptotic cell death (Su et al., 2019), and this peroxidative damage can be further exacerbated by reductions in the activity of glutathione peroxidase 4 (GPX4) and glutathione (GSH) together with enhanced malondialdehyde (MDA) activity (Conrad and Sato, 2012
Its detoxifying effects may enhance hormone balance and cellular integrity, creating a healthier environment for conception
After a traditional lunch, we will go into the jungle, taking an ethno botanical walk along the tambopata trails, learning about the medicinal plants and trees of the region, and observing the impressive Amazonian ecosystem, where we can see walking palm trees, the Lupuna Museums, snakes, etc