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These were clinical trials, cohort studies, or retrospective analyses examining drug-induced toxicities (hematological, hepatic, renal) and resistance mechanisms (rRNA mutations, -lactamase production) [1, 41, 66, 129]

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R 3 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 7 heterocycloalkyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 3 -C 9 heteroaryl, OR 6 , NR 5 R 6 , C(O)R 7 , -0O 2 R 6 , C(O)NR 5 R 6 , N(R 5 )C(O)R 7 , N(R 5 )CO 2 R 7 , NHS(O) 2 R 7 , S(O) 2 NR 5 R 6 , or R 2 and R 3 together form an optionally substituted C 2 -C 7 heterocycloalkyl ring

Here, two palmitic acids in coffee kahweol and cafestol palmitate are absorbed into the portal vein system, which leads directly to your liver