glutathione hydrolase Schematic overview of (GSH) metabolism and the targeting Sexual dimorphism in glutathione metabolism – Possible reaction mechanism of the

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Nguyen LNT, Pyburn JS, Nguyen NL, Schank MB, Zhao J, Wang L, Leshaodo TO, El Gazzar M, Moorman JP, Yao ZQ

Several studies have shown that H 2 S itself activates angiogenesis in cancer, 161,162,163,164 evidence that was used to develop strategies to promote the release of H 2 S and the activation of angiogenesis under certain pathological circumstances, such as wound healing 165,166 and inflammatory diseases

A 2025 study in Aging Cell confirmed these findings in both normal epithelial and fibroblast cell lines, identifying hTERT upregulation as the primary mechanism in normal cells (4)