Early gestational hCG elevation, sharing structural subunit homology with TSH, exerts mild thyroid-stimulating effects, physiologically elevating maternal thyroid hormone levels while suppressing TSH ( 5.1 Infectious etiologies of thyroid-reproductive dysfunction Beyond SARS-CoV-2, Cytomegalovirus (CMV) infection, present in 0.5-2% of pregnancies, triggers robust IL-6 and TNF- production from infected trophoblasts through viral protein US2-mediated activation of NF-B pathways, leading to disrupted placental thyroid hormone transporters (MCT8 and MCT10) and resulting in fetal hypothyroxinemia despite normal maternal thyroid function ( 5.2 Thyroid hormone associations: thyroid stimulation Thyroid-stimulating components encompass thyroxine (T4) and the more biologically active triiodothyronine (T3)
Care 58, 21012106
Burgos DF, Macho-Castello M, Iglesias-Cabeza N, Girldez BG, Gonzlez-Fernndez J, Snchez-Martn G, et al
Polyunsaturated fatty acids (PUFAs), which serve as the main substrates for lipid peroxidation, require esterification and incorporation into membrane phospholipidsespecially polyunsaturated fatty acid-phosphatidylethanolamine (PUFA-PE)to participate in ferroptosis signaling processes ( Fe 2+ within cells generates hydroxyl radicals (OH) through the Fenton reaction, thereby initiating the peroxidation of PUFAs ( - -GSH-GPX4 axis
