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The delayed antidepressant effects of SSRIs can be reduced by co-treatment of pindolol, a nonselective beta blocker with 5-HT 1A R antagonist activity ( 1A R partial agonist busipirone which has long been used to treat anxiety also demonstrates clinical efficacy when given in combination with SSRIs ( 1A R partial agonist properties, has been approved for treatment of major depressive disorder in adults ( 1A R antagonists and partial agonists attenuate adverse behavioral responses to antidepressants in adolescents, treatment for teen depression should take into consideration potential drug therapies with 5-HT 1A R antagonist activity to improve antidepressant efficacy, particularly during the initial period when adolescents are most vulnerable to the confounding effects of SSRI treatment
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