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Pulsed Doppler interrogation of mitral inflow was performed to measure peak early diastolic velocity (E), peak late diastolic velocity (A), their ratio E/A, E wave deceleration time, and isovolumic relaxation time

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However, concomitant treatment with both of these agents caused focal acinar atrophy, with slight intralobular and perivascular areas of fibrosis, and inflammatory cells infiltration resembling mild CP