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Although lowering of insulin levels with diet or drugs such as metformin and diazoxide seems generally beneficial, some practitioners also utilize strategic elevations of insulin levels in combination with chemotherapeutic drugs

Furthermore, geopolitical disparities obscure our understanding, as pediatric obesity research mostly emanates from high-income countries, while SAM-related data predominantly originates from low- and middle-income countries, thus insights from significant swaths of pediatric populations are left unexplored