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The "it clogs your pores" myth has been around for decades
NAPQI is neurotoxic : Crosses the placenta, depletes fetal brain glutathione, generates oxidative stress, and triggers cell death in neural tissue at doses below those causing maternal liver toxicity
Identity is confirmed by ESI mass spectrometry, purity is quantified by reverse-phase HPLC, and visual inspection verifies the integrity of the lyophilized cake and vial seal