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Exp Mol Med 49 , e322, (2017)

Platelet activation is caused by the breakdown of atheromatous plaque or the de-endothelialization of the arterial wall

Chicago Thomas, Liji

Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress