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Supplementation with high doses, extended periods of supplementation, or the combination of vitamin B12 with vitamins B1, B2, or B6, were suggested as possible causal factors of acneiform eruptions [5,6]

Consistent with this pathogenic axis, elevated plasma ET-1 in non-diabetic individuals has been reported as an independent predictor of incident prediabetes and T2DM [1015]

High blood pressure L-arginine has other potential health benefits, such as helping lower blood pressure in some people and improving walking distance in patients with off-and-on leg pain and weakness caused by poor blood flow (called intermittent claudication)

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