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Under glucose starvation conditions, damage to the pentose phosphate pathway can lead to a decrease in its metabolic product NADPH, resulting in a reduction in NADPH electron donors that prevent cystine from being converted to cysteine

The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer

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