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Here, we report for the first time an antioxidant function for LDHB in protecting KRAS -mutant lung cancer from ferroptosis, a ROS-dependent non-apoptotic cell death program triggered by iron- dependent accumulation of lipid peroxides in plasma membranes and intracellular organelles such as mitochondria [31]

Pregnancy dramatically increases acetaminophen toxicity risk : 80% increase in the toxic pathway, 43% HIGHER toxic NAPQI in first trimester, 33% LESS safe sulfation capacity, and glutathione depleted by 36-87% throughout pregnancy