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Thus, in the adipose tissue, physiological IGF-1 concentrations are not effective in stimulating changes in lipid synthesis or lipolysis, only at high concentrations is capable of stimulating glucose transport via the insulin receptor [182]

In the absence of completed and published phase I/II/III clinical trials, it is impossible to establish a complete profile of potential adverse effects in humans

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Novel delivery systems: Explore novel delivery systems such as liposomes and nanoparticles to enhance the retention time of polypeptides in the skin and improve their therapeutic effects