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Finally, designing advanced nanocarriers with improved stability, controlled release, and enhanced tumor penetration will further accelerate the clinical translation of GSH-responsive nanomedicine

Mechanistic investigations in the field have traditionally focused on single components, such as oocyte mitochondrial dysfunction [11, 12], local microenvironmental alterations [13,14,15], or epigenetic abnormalities [16,17,18]

In recent years, glutathione has gained significant attention in both the medical and cosmetic industries, particularly for its skin-brightening effects and overall health benefits

Despite promising results, these methods have remained experimental and are targeted toward patients already experiencing xerostomia