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Genes (Basel) 12 (10), 1581

Ethics approval and consent to participate This study was approved by the ethical committee on the use of animals for research, Department of Biotechnology, Federal University of Technology, Owerri, Nigeria in line with strict compliance with standard laboratory principles of animal care of the United States National Institute of Health (NIH, 1978)

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But it came with what researchers call "retinoid dermatitis": inflammation mediated by MCP-1 and IL-8 cytokine release, barrier disruption from transepidermal water loss, and photosensitivity from exposing fresh, immature cells to UV