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Signs and Symptoms of B12 Deficiency A lack of Vitamin B12 can show in many ways, including: Fatigue and Weakness : Early signs from not making enough red blood cells

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This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.