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The shared host-cell adhesion and haem-binding functionality of many NTHi proteins suggests that bacterial haem-utilisation plays an important role in its interplay with host epithelial cells and may provide an adaptive advantage for colonisation in environments with low haem-iron availability ( 4.2 Survivability and virulence in the respiratory tract Continued NTHi survival in the respiratory tract requires a secure source of host-derived haem

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