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The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance

[1] If a rash or generalized itching develops, the injection should be halted and the patient evaluated, as it could be a prodrome of a more serious reaction

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 1% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof