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Adjustments in bile composition also play a critical role in gallstone formation

Specifically, BRL37344 upregulated the expression of PPAR- and mCPT-1 while downregulating PPAR- and FAT/CD36, thereby reducing lipid accumulation in the liver and promoting -oxidation of fatty acids

This broader but still targeted approach means peptides can potentially address the network nature of psoriatic inflammation rather than just one node within it