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The glycocalyx is an important component of the vascular endothelial barrier

P2Y 2 receptor agonists, denufosol (OLIYNYK et al., 2010), were promising for their ability to activate alternative chloride secretion pathways, but both of these agonists have not been pursued further due to not meeting primary study goals of improving FEV 1 (Ratjen et al., 2012) and having a narrow effective concentration range, respectively (OLIYNYK et al., 2010)

For athletes, both substances may appear on the World Anti-Doping Agency (WADA) Prohibited List

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