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10.1007/s10787-017-0323-6 50 MihovilI.RadicB.BrcicL.BrcicI.VukojaI.IlicS.et al (2009)

Matrixyl has been evaluated in several double-blind, placebo-controlled studies showing reductions in wrinkle depth and improvements in skin texture

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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default