The trade-off is more frequent injections and more opportunities for measurement error
Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, Laframboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z (2016) Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
Interaction risk: Since DSIP may affect GABA and NMDA receptor activity, combining it with other sleep medications, alcohol, or sedatives could increase the risk of excessive drowsiness or neurological side effects
Yehuda & Mostofsky, 1989), but the modification has not yielded a binding probe that resolves the receptor question