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Cham: Springer Nature Switzerland

A., Pisalyaput, K

Sphingolipids Sphingolipids, a class of lipids with a sphingoid base backbone, are integral to the plasma membrane lipid bilayer, with sphingomyelin being a key component of membrane rafts

Figure 2B focuses on direct and incretin-mediated signaling to the -cell, depicting how BefA, LPS and microbial tryptophan metabolites act on intestinal epithelial and enteroendocrine cells to modulate GIP and GLP-1 secretion and how these hormones, together with BefA, engage GIPR/GLP1R, cAMPPKA/EPAC2 and PI3K/AKT pathways to regulate -cell Ca 2+ influx, survival, proliferation and insulin granule exocytosis