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Since Hu-antigen R (HuR) has been shown to stabilize SIRT1 mRNA by competing with tristetraprolin (TTP) for binding [29], future investigations should determine whether SYNCRIP competes or cooperates with other RBPs, such as HuR or TTP, and whether the interaction between SYNCRIP and the 3' UTR also affects miRNA-mediated regulation of SIRT1

Alongside this, there were corresponding improvements in metabolic health markers like triglycerides and HDL cholesterol

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Few long-term randomized trials measure major cardiovascular endpoints, so questions remain