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2 Molecular mechanisms of ferroptosis Ferroptosis, a novel form of cell death distinct from apoptosis, pyroptosis and autophagy, is an iron-dependent programmed form of cell death characterized by an iron metabolism disorder, imbalance of the redox system and the accumulation of lipid peroxides (6, 7)

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The MDT is inversely proportional to the release rate of an active agent from a formulation or device described herein

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