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Although the effects of PTU derivatives were primarily evaluated for their melanogenesis inhibition in B16 melanoma cells, later it was confirmed that it was due to inhibition of tyrosinase activity

Main body of the abstract The 70-kDa HSP (HSP70) expression is enhanced by glutamine, via the hexosamine biosynthetic pathway, which inhibits the NF-B pathway regenerating and recovering myofibers through the regulation of the early inflammatory response to muscle injury, which may be impaired by local and systemic inflammatory injury due to reduced intracellular levels of HSP70

Hashimoto Y, Kurita M, Aiso S et al (2009) Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor /WSX-1/gp130