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Such phosphorylation leads to the blockade of the tyrosine residues in IRSs, to which the insulin and IGF-1 receptors phosphorylate to activate IRSs and consequently commence the signalling cascade [185, 192], as comprehensively discussed above

Inasmuch, these complications have caused fear and controversy among studies and opinions towards the safety of the treatment even when there are findings supporting the need for further investigation in the field of metabolic disorders

Proper administration secures optimal results, prevents damage to the surrounding tissue, and reduces pain and discomfort

Abnormal IGF-1 and GH levels have been proposed to play a key role in obesity [130, 240, 241]