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Antimicrobial activity of gallium compounds on ESKAPE pathogens

Tamoxifen-induced oxidative stress increased the accumulation of the transcription factor, Nuclear factor-erythroid 2-related factor-2 (Nrf2), which activates the anti-oxidant response element (ARE) 34,35 and this contributes to chemo-resistance 36,37,38

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These macrophages, potentially skewed towards a pro-inflammatory M1 phenotype due to iron accumulation [93], are potent sources of both inflammatory cytokines and key pro-fibrotic mediators like TGF-, thereby directly connecting iron processing by immune cells to the fibrotic process