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AOP: 209 Title A descriptive phrase which references both the Molecular Initiating Event and Adverse Outcome.It should take the form MIE leading to AO

Their high receptor specificity and relatively low toxicity profiles (compared to small molecules or full-length proteins) have made them central to 21st-century drug discovery

As an example, immunopathologic vasculopathy in a hypoxic model of pulmonary hypertension was found to be driven by G6PD-induced pro-inflammatory epigenetic signaling including upregulated expression of pro-inflammatory factors (e.g., tumor necrosis factor-alpha [TNF-]), increased numbers of activated macrophages, and activated platelets and conversely, was able to be mitigated with G6PD deficiency (15, 16)

Building on these results, a phase 1b trial in individuals with T2D further evaluated the safety, pharmacokinetics, and pharmacodynamics of once-weekly retatrutide over 12 weeks [43]