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A method for preventing drug-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent, wherein the therapeutic agent is an antioxidant or anti-apoptotic agent, wherein the pharmaceutical composition is administered prior to onset of therapy with the drug, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration

Injectable versions that are prescribed by healthcare professionals can be manufactured within FDA-regulated and compliant pharmacies and undergo multiple levels of testing for efficacy and sterility

An iatrogenic IV overdose of paracetamol was the subject of a Scottish fatal accident inquiry [89, 90]

Nature 540 , 270275 (2016)