The search strategy was developed using keywords and Boolean operators such as rumen-protected methionine, methionine supplementation AND dairy cows, and methionine supplementation AND beef cattle. After retrieval, duplicate records, in vitro studies, literature reviews, and meta-analyses were removed
Natural IGF-1 has a very short lifespan (half life) and likes to bind with other proteins that can change laboratory-based test results
In addition, tryptophan depletion and kynurenine accumulation induce the formation of immunosuppressive regulatory T cells (Tregs), leading to tumor growth (Heng et al., 2016)
This observation aligns well with the crucial ability of viruses to interact with host proteins (for example in the Potyviridae family), leading to the induction and support of virus infection in different hosts (Yang et al., 2021)