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J Neuroimmune Pharmacol 16 , 7489 (2021)

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34,35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36,37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38,39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals

Melittin lowers the high mortality rate, alleviates hepatic pathological damage, suppresses hepatocyte apoptosis, and suppresses hepatic inflammatory responses (Jafari et al., 2024)