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Handbook of Experimental Pharmacology, 200, 3391

2.4 Effects of metabolism on immune cells in the TME Tumor-infiltrating immune cells have dual characteristics, some of which have the function of inhibiting tumor proliferation and metastasis, such as CD8+ cytotoxic T cells, natural killer (NK) cells, M1 macrophages, dendritic cells (DCs), etc., while others may be beneficial to tumor development, including Treg cells, M2 macrophages (78)

TP53 also influences ferroptosis sensitivity through other mechanisms, such as downregulating VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1) in vitamin K metabolism [151] and inducing SAT1 (spermidine/spermine N1-acetyltransferase 1), an enzyme in polyamine catabolism that produces ROS [152]

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