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Glutamate is converted to KG, an intermediate in the TCA cycle in glutaminolysis, which activates the TCA cycle, although much remains exported by xCT in exchange for extracellular cystine [16]

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In an in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis

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