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In contrast, M2-like macrophages, driven by oxidative phosphorylation, fatty-acid -oxidation, and glutathione synthesis, constitute a ferroptosis-inhibitory niche

Because glutathione levels naturally fluctuate based on oxidative stress and toxic exposure, consistent daily supplementation is often required to maintain elevated cellular stores

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COVID-19 neurotropism and PD: exploring the links The CNS has been disrupted by COVID-19 in a variety of ways, including direct SARS-CoV-2 invasion of neuronal cells, huge inflammatory elements driven by severe systemic inflammation flowing into brains, respiratory failure linked brain ischemia, etc [18,19,20]