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doi: 10.3389/fendo.2023.1238927 154 HattoriYSuzukiKHattoriSKasaiK

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Advantages: Localized delivery to target tissue (skin, scalp) Non-invasive Lower systemic exposure Well-tolerated with established safety record in cosmeceuticals Limitations: Limited dermal penetration (molecular weight ~340 Da near the cutoff for transdermal absorption) No systemic anti-aging or anti-inflammatory effects Efficacy dependent on formulation vehicle (liposomal carriers significantly improve penetration) GHK-Cu Injection (Subcutaneous) GHK-Cu injection is explored in research settings for systemic administration

The goal of this project was to chemically modify this tripeptide in such a way to enhance its metabolic stability and barrier permeability to produce a drug candidate with potential clinical utility