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Neuroprotection and neuronal cell studies: Assessing neurotrophic and neuroprotective responses in primary neuronal cultures and rodent central nervous system injury models

Interestingly, extraneural alterations in the production of ECM under the influence of melatonin have been described in other tissuesmelatonin has turned out to upregulate the levels of collagen II, collagen X and aggrecan in chondrogenic mesenchymal stem cells (Gao et al., 2014), and increase the expression of glycoproteins, fibronectin and laminin in several cancer cell lines (Sung et al., 2016)

This arm of the mechanism is also believed to drive PCSK9 degradation, which appears to lower LDL cholesterol in clinical readouts

More recently, Iwata et al