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Vitamin B12 injections are also gaining in popularity and availability

Additionally, CD117 is expressed at high levels in OCSCs and plays a role in tumor initiation and resistance to cisplatin/paclitaxel by activating the Wnt/-catenin-ABCG 2 pathway (76)

Additionally, they can reduce the expression and activity of key iron uptake proteins such as transferrin receptor, divalent metal transporter 1 (DMT1), and zinc-iron transporters, while also modulating critical regulatory factors including iron-regulated proteins and hypoxia-inducible factor 1 (27)

In agreement with in vitro findings, DMF treatment induced the expression of Cbs, Ahcy, and NRF2 targets such as Gclc, Gclm, and Slc7a11, but not that of Cse (Fig