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5c) were associated with regulating epithelial cell proliferation (GO:0050678)

More recently, gene profiling data from the Broad Institutes Connectivity Map has positioned GHK-Cu as one of the most broadly studied peptides in the context of gene expression modulation, with data suggesting influence over tissue repair, antioxidant defense, and anti-inflammatory pathways simultaneously

In addition, a positive correlation between serum UA and total insulin secretion has been reported using a hyperglycemic clamp technique in type 2 diabetic patients without hyperuricemia [43]

The development of new models in which these pathways can be manipulated will aid this research and enable further investigation of promising therapeutic targets