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Its Innovative Science and Technology Approaches for New Drugs (ISTAND) pilot program is explicitly considering complex in vitro models like OoCs, with a liver-on-chip for DILI being the first OoC accepted into the program for evaluation (222)

Therefore, in spite of the statistical significance, the absolute number of cases was extremely low

Ipamorelin (Novo Nordisk) is the selective pentapeptide: ~13 GH elevation, with no increase in cortisol or prolactin even at 200 the ED50 GH (Raun 1998)

A study found that RA-XII, derived from Taxus yunnanensis , could prevent the growth and metastasis of colorectal tumors at an IC50 value of 5 M by affecting some cellular signaling pathways (48)