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Fertirelin, as a GnRH analogue, elicits its action by binding to GnRH receptors located on pituitary gonadotroph cells

[10] Enzyme-inducing anticonvulsants such as phenytoin, carbamazepine, and phenobarbital, as well as rifampicin, accelerate hepatic catabolism of vitamin D, shortening its half-life and potentially necessitating more frequent or higher intramuscular doses to sustain target 25-hydroxyvitamin D levels

Administering the peptide at night aligns with this rhythm, producing a compounded effect

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