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These drugs mimic the binding of the naturally produced GLP-1 hormone to its cognate receptor after food intake, which has the effect of regulating glucose homeostasis, lipid metabolism, gastric emptying and feelings of satiety 19 (Figure 1)

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This requires finer stratification of subjects in clinical trial design, conducting subgroup analysis based on clinical phenotypes, metabolic status, and biomarker levels to screen patient populations most likely to benefit

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