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Angiotensin-Converting Enzyme (ACE) Inhibitors: Drugs like enalapril and lisinopril, used for high blood pressure, can cause serious fetal harm, particularly in the second and third trimesters

Moreover, rats treated with 1% neohesperidin dihydrochalcone for 1 month showed reduced amygdala neuroinflammation via suppression of cAMP/PKA pathway activity, restoration of cortical 5-HT, DA, and NE levels, and reversal of anxiety- and depression-like behaviors (Jiang et al., 2023)

Because H 2 S and Fe 2+ are abundant in hydrothermal environments, primitive organisms likely extracted two electrons of reducing power from oxidation of H 2 S, which then coupled with Fe 2+ , yielding pyrite (FeS 2 )[20]

Fratta Pasini et al., 2021), targeting Nrf2 is therefore essential for the treatment of diseases characterized by enhanced oxidative stress and inflammation, such as aging and COVID-19-induced pneumonia and ARDS (Lewis et al., 2010