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Maintenance and discontinuation SURMOUNT-4, continue vs placebo switch after lead-in to about 20.9% loss: stopping regained about +14% over 52 weeks while continuing lost a further -5.5%

396 Increasing evidence shows that disturbances in neurotransmitter systems, including the glutamate, GABA, serotonin (5-hydroxytryptamine, 5-HT), 397,398 melatonin, 397,399 dopamine (DA), 396,400,401 OT and arginine vasopressin (AVP) systems, are associated with autism (Fig