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Abbreviations ALSFRS-R: Revised amyotrophic lateral sclerosis functional rating scale CSF: Cerebrospinal fluid Cys: Cysteine GSH: Reduced glutathione GSH*: Glycine- 13 C 2 , 15 N-Glutathione tGSH: Total glutathione GS-NEM: Derivatisation of GSH by NEM tGS-NEM: Derivatisation of tGSH by NEM GSSG: Oxidised glutathione HC: Healthy control group HPLC: High-pressure liquid chromatography ALS: Amyotrophic lateral sclerosis MRM: Multiple reaction monitoring MS: Mass spectrometry NEM: N-Ethylmaleimide TCEP: Tris(2-carboxyethyl)phosphine References Barber SC, Mead RJ, Shaw PJ

3 European Journal of EndocrinologyRaun et al

GH also increases muscle mass, strength, and reduces body fat

Another hypothesis, proposed by the authors, was that ketone metabolism might be more related to non-motor symptoms, which the results seem to reflect