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Studies examine: VEGFR2 activation pathways and intracellular adaptor protein recruitment Focal adhesion kinase (FAK) phosphorylation mechanisms Paxillin recruitment and integrin-actin cytoskeleton interactions Endothelial cell proliferation and migration assays in vitro Research models study the combined effects of VEGFR2-mediated proliferation and FAK-paxillin-mediated cellular motility in angiogenesis pathway investigations

The observed differential mRNA and protein expression levels of GPX4 and TfR1 in vitro may bear clinical relevance when considering factors such as tumor heterogeneity and the wide-ranging therapeutic response of thyroid tumors harboring diverse mutational signatures

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