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Bao et al

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They work intracellularly to block the JAK/STAT signaling pathway, effectively intercepting the downstream signaling of multiple pro-inflammatory cytokines that drive RA tofacitinib mono-therapy has been found to be superior to methotrexate in reducing the symptoms and progression of RA

However, it does provide a bit more evidence as to how a diet high in animal products may promote CAD and suggests a plausible mechanism to help explain why a low-fat, near vegetarian diet appears more effective than statin drugs for reversing atherosclerosis, even though the drugs are more effective in high doses at lowering LDL-C levels