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Oral preconditioning of rats with 50 or 100 mg/kg/day for 7 days significantly reduced markers of liver damage (ALT, AST, and lipid peroxidation) following experimental acetaminophen overdose (Girish 2009)

Glutathione is responsible for disarming free radicals, recycling other antioxidants, and encouraging cell turnover and collagen production

Secondly, the combination of different functional nanoagents may cause corresponding toxic side effects to the human body, thus the biodegradability, stability, and safety of nanomedicines still need further validation

In China, supportive policies like accelerated approval pathways for urgently needed orphan drugs (UNOD) and Care for Rare Diseases Encouragement (CARE) plan 28 , have been implemented to improve access to therapies for rare conditions