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While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort

Each specimen/sample was examined for abnormalities, including icteric, lipemic, lysis, and turbidity

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An increase in nitric oxide content brings on a nitrosative stress and generates the toxic, unstable structural isomer of nitrate peroxynitrite (ONOO-), triggering apoptosis and eventually causing myocardial injury 45